My recommended daily intake of Vitamin D3 (the active form of the vitamin hormone): 5,000 to 10,000 iu daily
On November 30, 2010, the Instute of Medicine (IOM) published on line atheir report concerning “Dietary Reference Intake for Calcium and Vitamin D”.
The link is as follows:
You will be uterally amazed at the following statement: “The IOM finds that the evidence supports a role for vitamin D and calcium in bone health but not in other health conditions. Further, emerging evidence indicates that too much of these nutrients may be harmful, challenging the concept that “more is better.”
I can’t believe they said that!
The following published articles are rather straight forward and to the point.
1. Am J Clin Nutr. 2007 Sep;86(3):645-51.
Safety of vitamin D3 in adults with multiple sclerosis.
Kimball SM, Ursell MR, O’Connor P, Vieth R.
From the Department of Nutritional Sciences, University of Toronto, Toronto, Canada.
Report on 12 patients with multiple sclerosis were given 1200 mg elemental Ca/d along with progressively increasing doses of vitamin D3: from 700 to 7000 microg/wk (from 28 000 to 280 000 IU/wk) for 28 weeks.
Main point of the article:
Current results provide objective evidence that vitamin D intake beyond the current upper limit is safe by a wide margin.
2. J Neurol. 2009 Sep;256(9):1468-79. Epub 2009 Apr 28.
Clinical implications of a possible role of vitamin D in multiple sclerosis.
From,Service de Neurologie 1, Hôpital de la Salpêtrière, Assistance Publique, Hôpitaux de Paris, 75657 Paris Cedex 13, France.
Main points of the article:
a) The most studied environmental risk factor for multiple sclerosis is a low level of vitamin D
b) Clinically, most MS patients have low serum levels of vitamin D and are in a state of insufficiency or even deficiency
c) Vitamin D prevents and improves experimental autoimmune encephalomyelitis in animal studies.
d) Exposure to sun and the serum level of vitamin D influence the risk of MS
3. Proc. Natl. Acad. Sci. USA, Vol 93, pp.7861-7864, July 1996, Immunology
1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis
MARGHERITA T. CANTORNA, COLLEEN E. HAYES, AND HECTOR F. DELUCA*
From the Department of Biochemistry, University of Wisconsin, 420 Henry Mall, Madison, WI 53706
Take home message:
a) Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease model for the human disease multiple sclerosis (MS).
b) EAE was completely prevented by the administration of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. 1,25-(OH)2D3 could also prevent the progression of EAE when dministered at the appearance of the first disability symptoms.
c) A deficiency of vitamin D resulted in an increased susceptibility to EAE.
To Your Health,
Dr. Rudy Cartwright
PS: As always, please leave your comments below.